2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine
• CAS No.: 103660-32-8
• Molecular Formula: C₁₆H₁₉NO₃
• Molecular Weight: 273.332
• Mol file: 103660-32-8.mol

Synonyms:2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine

Chemical Property of 2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine

There total 1 articles about 2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-azabicyclo[2.2.1]heptan-3-one (21472-89-9) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine (103660-32-8)

Guidance literature:

With sodium hydroxide; In ethanol; 1) 5 h, reflux, 2) 16 h, 20 deg C;

DOI:10.1007/BF00515032

Reference yield: 90.0%

2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine (103660-32-8) → 2-(3,4-dimethoxybenzyl)-3-oxoquinuclidine (103660-57-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In hydrogenchloride; methanol; at 20 ℃;

DOI:10.1007/BF00515032

Reference yield: 65.0%

2-(3,4-dimethoxyphenylmethylene)-3-oxoquinuclidine (103660-32-8) → 4a-hydroxy-7-(3,4-dimethoxyphenyl)-4a,5,7,7a-tetrahydropyrazolo<4,3-b>quinuclidine (103660-36-2)

Guidance literature:

With hydrazine hydrate; In ethanol; 1) 60 deg C, 2 h, 2) 4 deg C, 20 h;

DOI:10.1007/BF00515032

upstream raw materials:

1-azabicyclo[2.2.1]heptan-3-one

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

3-(4-piperidyl)-5-(3,4-dimethoxyphenyl)pyrazole

4a-hydroxy-7-(3,4-dimethoxyphenyl)-4a,5,7,7a-tetrahydropyrazolo<4,3-b>quinuclidine

2-(3,4-dimethoxybenzyl)-3-oxoquinuclidine

2-(3,4-dihydroxybenzyl)quinuclidine