tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

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Chemical Name:tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide
CAS No.:476194-63-5
Molecular Formula:C₂₄H₃₆N₂O₉S
Molecular Weight:528.624
Hs Code.:

Synonyms:tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

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Chemical Property of tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

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Technology Process of tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

There total 8 articles about tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1365682-50-3
C₁₉H₂₇NO₈S

: 476194-63-5
tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 - 40 ℃; for 3.5h;

Reference yield:

: 476192-12-8
4-[(4-fluorophenyl)sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid, 1,1-dimethylethyl ester

: 476194-63-5
tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / 4 h / 0 - 20 °C

2: 5% Pd(II)/C(eggshell) / tetrahydrofuran / 1.5 h / 4137.29 Torr

3: sodium periodate; ruthenium trichloride / tetrachloromethane; water

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h

5: trifluoroacetic acid

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 19.5 h / 20 - 40 °C

With ruthenium trichloride; sodium periodate; 5% Pd(II)/C(eggshell); sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.095

Reference yield:

: 476192-21-9
C₂₃H₃₅NO₈S

: 476194-63-5
tetrahydro-4-[[4-[[5-(methoxy-methylamino)-5-oxopentyl]oxy]phenyl]sulfonyl]-N-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 19.5 h / 20 - 40 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.095