methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate

Base Information

• Chemical Name: methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate
• CAS No.: 864784-02-1
• Molecular Formula: C₂₈H₂₆N₂O₆
• Molecular Weight: 486.524

Synonyms:methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate

Chemical Property of methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate

There total 2 articles about methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-(4-methoxybenzyl)-N-phenyl but-2-ynamide (864784-00-9) + methyl α-(2-nitrophenyl)acrylate (494836-60-1) → methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate (864784-02-1)

Guidance literature:

With tributylphosphine; In benzene; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2005.06.050

Reference yield:

N-(4-methoxybenzyl)aniline (3526-43-0) → methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate (864784-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / HOBt; EDCI / acetonitrile / 15 h / 20 °C

2: 55 percent / Bu₃P / benzene / 48 h / 20 °C

With tributylphosphine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; benzene;

DOI:10.1016/j.tet.2005.06.050

Reference yield: 16.0%

methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate (864784-02-1) → 2-oxo-N-phenyl-N-(4-methoxybenzyl)-spiro[3'-cyclopentene-1',3-[3H]indole]-3'-carboxamide (864784-03-2)

Guidance literature:

With acetic acid; zinc; for 1.5h;

DOI:10.1016/j.tet.2005.06.050

upstream raw materials:

N-(4-methoxybenzyl)-N-phenyl but-2-ynamide

methyl α-(2-nitrophenyl)acrylate

N-(4-methoxybenzyl)aniline

Downstream raw materials:

2-oxo-N-phenyl-N-(4-methoxybenzyl)-spiro[3'-cyclopentene-1',3-[3H]indole]-3'-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 864784-02-1 methyl 3-[(4-methoxyphenyl)phenylcarbamoyl]-1-(2-nitrophenyl)-cyclopent-3-enecarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send