N-(4-Methoxybenzyl)aniline

Base Information

• Chemical Name: N-(4-Methoxybenzyl)aniline
• CAS No.: 3526-43-0
• Molecular Formula: C14H15NO
• Molecular Weight: 213.279
• Hs Code.: 2922299090
• European Community (EC) Number: 621-214-6
• UNII: Z537UA4VGX
• DSSTox Substance ID: DTXSID701290336
• Nikkaji Number: J455.571F
• ChEMBL ID: CHEMBL258517
• Mol file: 3526-43-0.mol

Synonyms:N-(4-Methoxybenzyl)aniline;3526-43-0;N-Phenyl-4-methoxybenzylamine;(4-Methoxy-benzyl)-phenyl-amine;N-[(4-methoxyphenyl)methyl]aniline;4-Methoxy-N-phenylbenzenemethanamine;p-Methoxy-N-phenylbenzylamine;4-Methoxy-N-Phenylbenzylamine;Benzylamine, p-methoxy-N-phenyl-;N-(p-Methoxybenzyl)aniline;4-Methoxybenzyl(phenyl)amine;Z537UA4VGX;Benzenemethanamine, 4-methoxy-N-phenyl-;N((-4-Methoxyphenyl)methyl)aniline;UNII-Z537UA4VGX;(4-Methoxybenzyl)phenylamine;Oprea1_211513;Oprea1_874991;N-(4-methoxybenzyl)benzenamine;CHEMBL258517;SCHEMBL2306553;M-XYLENE-4-SULFONICACID;N-Phenyl-(p-methoxybenzyl)amine;DTXSID701290336;CL8688;MFCD00025831;STK730498;(4-methoxyphenyl)-methyl-phenyl-amine;AKOS000223047;AM84098;SB78934;NCGC00340746-01;AS-46076;A6193;CS-0150388;FT-0690446;AB00088868-01;AB00088868-04;Z266463582

Chemical Property of N-(4-Methoxybenzyl)aniline

Chemical Property:

• Boiling Point: 349.27 °C at 760 mmHg
• Flash Point: 141.735 °C
• PSA: 21.26000
• Density: 1.102 g/cm³
• LogP: 3.38030
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

N-Phenyl-4-methoxybenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNC2=CC=CC=C2

Technology Process of N-(4-Methoxybenzyl)aniline

There total 115 articles about N-(4-Methoxybenzyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-methoxy-benzaldehyde (123-11-5) + nitrobenzene (98-95-3,26969-40-4) → N-(4-methoxybenzyl)aniline (3526-43-0) + 4-Methoxybenzyl alcohol (105-13-5)

Guidance literature:

nitrobenzene; With triethylsilane; palladium; In methanol; for 2h; under 760.051 Torr;

4-methoxy-benzaldehyde; In methanol;

DOI:10.1016/j.inoche.2020.108143

Reference yield: 91.0%

4-methoxy-benzaldehyde (123-11-5) + aniline (62-53-3) → N-(4-methoxybenzyl)aniline (3526-43-0) + 4-Methoxybenzyl alcohol (105-13-5)

Guidance literature:

With triethylsilane; palladium; In methanol; for 6h; under 760.051 Torr;

DOI:10.1016/j.inoche.2020.108143

Reference yield: 84.0%

N-phenylbenzamidine (1527-91-9) + 4-Methoxybenzyl alcohol (105-13-5) → N-(4-methoxybenzyl)aniline (3526-43-0) + benzamide (55-21-0,27208-38-4)

Guidance literature:

With potassium hydroxide; In toluene; at 120 ℃; for 15h; Schlenk technique; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.0c00281

upstream raw materials:

formaldehyd

methoxybenzene

aniline

p-methoxybenzyl chloride

Downstream raw materials:

N-(4-methoxy-benzyl)-N-(1-methyl-[4]piperidyl)-aniline

diisopropyl-{2-[(4-methoxy-benzyl)-phenyl-carbamoyloxy]-ethyl}-methyl-ammonium; iodide

N-(4-methoxy-benzyl)-N-(2-piperidino-ethyl)-aniline

N²-(4-methoxy-benzyl)-N¹,N¹,N³,N³-tetramethyl-N²-phenyl-propane-1,2,3-triyltriamine