Technology Process of (4S)-2,2-dimethyl-4-[(Z)-phenylethenyl]-1,3-dioxolane
There total 4 articles about (4S)-2,2-dimethyl-4-[(Z)-phenylethenyl]-1,3-dioxolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzyltriphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.25h;
2,3-isopropylidene-glyceraldehyde;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 0.5h;
Overall yield = 90 %; Overall yield = 2.82 g;
DOI:10.24820/ark.5550190.p010.461
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonium molybdate; dihydrogen peroxide / ethanol / 0 - 25 °C / Inert atmosphere
2: potassium hexamethylsilazane; tetrabutylammomium bromide / tetrahydrofuran / 15 h / -78 - 25 °C / Inert atmosphere
With
ammonium molybdate; tetrabutylammomium bromide; dihydrogen peroxide; potassium hexamethylsilazane;
In
tetrahydrofuran; ethanol;
2: |Julia-Kocienski Olefination;
DOI:10.1039/d1ob02126e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / paraffin oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 25 °C / Inert atmosphere
2.1: ammonium molybdate; dihydrogen peroxide / ethanol / 0 - 25 °C / Inert atmosphere
3.1: potassium hexamethylsilazane; tetrabutylammomium bromide / tetrahydrofuran / 15 h / -78 - 25 °C / Inert atmosphere
With
ammonium molybdate; tetrabutylammomium bromide; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride;
In
tetrahydrofuran; ethanol; paraffin oil;
3.1: |Julia-Kocienski Olefination;
DOI:10.1039/d1ob02126e
