5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Base Information

Chemical Name:5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide
CAS No.:1351066-94-8
Molecular Formula:C₃₃H₄₆N₂O₂Si₂
Molecular Weight:558.911
Hs Code.:

Synonyms:5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

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Technology Process of 5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

There total 4 articles about 5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1351067-35-0
3-[(tert-butyldimethylsilyl)oxy]-N-(quinolin-8-yl)benzamide

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1351066-94-8
5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: With cesium acetate; palladium diacetate; In toluene; at 110 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol203100u

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1351066-94-8
5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: cesium acetate; palladium diacetate / toluene / 24 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; cesium acetate; palladium diacetate; silver nitrate; In toluene;
DOI:10.1021/ol203100u

Reference yield:

: 160907-95-9
3-((tert-butyldimethylsilyl)oxy)benzoic acid

: 1351066-94-8
5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: cesium acetate; palladium diacetate / toluene / 24 h / 110 °C / Inert atmosphere

With oxalyl dichloride; cesium acetate; palladium diacetate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/ol203100u