1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

Base Information

Chemical Name:1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione
CAS No.:460744-78-9
Molecular Formula:C₂₂H₂₈O₇Si
Molecular Weight:432.546
Hs Code.:

Synonyms:1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

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Chemical Property of 1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

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Technology Process of 1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

There total 3 articles about 1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 528-21-2
2',3',4'-trihydroxyacetophenone

: 157665-69-5
methyl 3-{[tert-butyldimethylsilyl]oxy}-4-methoxybenzoate

: 460744-78-9
1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

Guidance literature:: 2',3',4'-trihydroxyacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -10 ℃; for 3h;

methyl 3-{[tert-butyldimethylsilyl]oxy}-4-methoxybenzoate; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jm040810b

Reference yield:

: 6702-50-7
3-hydroxy-4-methoxybenzoate

: 460744-78-9
1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / N-ethyldiisopropylamine / dimethylformamide / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 3 h / -78 - -10 °C

2.2: 45 percent / tetrahydrofuran / -78 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm040810b

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 460744-78-9
1-(3-{[tert-butyldimethylsilyl]oxy}-4-methoxyphenyl)-3-(2,3,4-trihydroxyphenyl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / N-ethyldiisopropylamine / dimethylformamide / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 3 h / -78 - -10 °C

2.2: 45 percent / tetrahydrofuran / -78 - 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm040810b