N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Base Information

Chemical Name:N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide
CAS No.:94193-00-7
Molecular Formula:C₂₄H₃₂N₄O₅
Molecular Weight:456.542
Hs Code.:

Synonyms:N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Chemical Property of N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

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Technology Process of N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

There total 9 articles about N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 108-24-7
acetic anhydride

: 94192-60-6
N-cyclohexyl-N-(2-hydroxyethyl)-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide

: 94193-00-7
N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: With dmap; In pyridine; for 1h; Ambient temperature;
DOI:10.1021/jm00385a012

Reference yield:

: 2842-38-8
cyclohexyl(2-(hydroxy)ethyl)amine

: 94193-00-7
N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: Na₂CO₃ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: H₂ / 10percent Pd/C / ethanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

6: 66 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1021/jm00385a012

Reference yield:

: 94193-39-2
N-Cyclohexyl-4-(3-formyl-4-nitro-phenoxy)-N-(2-hydroxy-ethyl)-butyramide

: 94193-00-7
N-(2-acetoxyethyl)-N-cyclohexyl-4-<(1,2,3,5-tetrahydro-2-oxoimidazo<2,1-b>quinazolin-7-yl)oxy>butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AcONa / ethanol / 0.5 h

2: NaBH₃CN / ethanol / 3 h

3: H₂ / 10percent Pd/C / ethanol

4: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

5: 66 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; palladium on activated charcoal; In pyridine; ethanol;
DOI:10.1021/jm00385a012