2842-38-8

Basic information

• Product Name: N-CYCLOHEXYLETHANOLAMINE
• Synonyms: TIMTEC-BB SBB007725;N-(2-HYDROXYETHYL)CYCLOHEXYLAMINE;N-CYCLOHEXYLETHANOLAMINE;2-(cyclohexylamino)-ethano;Abbomeen e-25 aerosol;abbomeene-25aerosol;Abromeen e-25;abromeene-25
• CAS NO: 2842-38-8
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.23
• EINECS: 220-636-4
• Mol File: 2842-38-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 36°C
• Boiling Point: 115-118°C 10mm
• Flash Point: 115-118°C/10mm
• Appearance: /
• Density: 0.9636 (rough estimate)
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.4614 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility: almost transparency
• BRN: 1071413
• CAS DataBase Reference: N-CYCLOHEXYLETHANOLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEXYLETHANOLAMINE(2842-38-8)
• EPA Substance Registry System: N-CYCLOHEXYLETHANOLAMINE(2842-38-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• RTECS: KK3530000
• Hazardous Substances Data: 2842-38-8(Hazardous Substances Data)

Usage

General Description

N-Cyclohexylethanolamine, also known as N-chexanol, is a chemical compound with the molecular formula C8H17NO. It is a clear, colorless to pale yellow liquid with a faint amine-like odor. N-cyclohexylethanolamine is commonly used as an intermediate in the manufacturing of surfactants, corrosion inhibitors, and lubricant additives. It is also utilized as a pH buffer in personal care products and as a catalyst in polymerization reactions. Additionally, N-cyclohexylethanolamine is employed in the synthesis of agricultural chemicals and pharmaceuticals. While the compound is considered to have low acute toxicity, its potential chronic health effects and environmental impact should be carefully considered and managed when using this chemical.

InChI:InChI=1/C8H17NO/c10-7-6-9-8-4-2-1-3-5-8/h8-10H,1-7H2

Upstream product

• 108-85-0 1-bromocyclohexane 
• 141-43-5 ethanolamine 
• 108-93-0 cyclohexanol 
• 177-04-8 1-oxa-4-azaspiro[4.5]decane 
• 1586805-14-2 C₁₂H₂₃NO 
• 108-91-8 cyclohexylamine 
• 108-94-1 cyclohexanone 
• 96-49-1 [1,3]-dioxolan-2-one 
• 64-17-5 ethanol 
• 54961-36-3 1-(2-hydroxy-ethylamino)-cyclohexanecarbonitrile 
• 155052-20-3 4-Aza-2-oxo-1-oxaspiro<5.4>dec-3-ene 4-oxide 
• 27110-20-9 4-Cyclohexyl-1-oxa-4-aza-spiro[4.5]decane 
• 122-98-5 2-Anilinoethanol 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 635751-42-7 2-[Cyclohexyl[[(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazol-1-yl]carbonyl]amino]ethyl ethyl carbonate 
• 635750-93-5 2-(cyclohexylamino)ethyl ethyl carbonate hydrochloride 
• 1397956-73-8 3-((cyclohexyl(2-hydroxyethyl)amino)methyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one 
• 1147998-76-2 N-(2-[(6-chloropyrazin-2-yl)oxy]ethyl)cyclohexanamine 
• 1221413-87-1 4-(2-cyclohexylamino)ethoxybenzaldehyde 
• 1133820-36-6 C₁₇H₂₇NO₆ 

Relevant articles and documents

Indirect monoalkylation of primary and secondary amines by reductive decyanation of α-aminonitriles with sodium cyanoborohydride-mercury bis(trifluoroacetate)

Secondary and tertiary amines are prepared from α-aminonitriles by selective reductive cleavage of the cyanide moiety. The α-aminonitriles in this case, function as 'masked' imine or iminium ions and are 'unmasked' by mercury(II) in the presence of sodium cyanoborohydride to obtain the reduced product. Secondary amines may be prepared indirectly from primary amines in good yield without danger of over alkylation.

Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors

A series of novel hydroxyethylaminomethylbenzimidazole analogs 5a-y were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, 2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino)butan-1-ol (5e, 94.3% inhibition at 30 μM, IC50 = 3.5 μM, cLogP = 4.132) and 3-cyclohexyl-2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino) propan-1-ol (5k, 94.7% inhibition at 30 μM, IC50 = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR (Fig. 5) indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon play an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of 5e and 5k with normal B lymphoblasts revealed that they had no significant effects on cell viability.

Synthesis of pyrrole N-derivatives from oxazolidines

Transformations of oxazolidine derivatives synthesized from industrially produced amino alcohols, aldehydes, and ketones under basic or acidic catalysis lead to the formation of N-alkyl- and N-(hydroxyalkyl)-substituted pyrroles in 19-81% yields.