2842-38-8

Usage

Uses

Used in Surfactant Production:
N-Cyclohexylethanolamine is used as an intermediate in the manufacturing of surfactants for its ability to enhance the performance and stability of these compounds in various applications.
Used in Corrosion Inhibitor Formulation:
It serves as an intermediate in the production of corrosion inhibitors, where it helps to prevent or reduce the corrosion of metals, particularly in industrial settings.
Used in Lubricant Additive Synthesis:
N-Cyclohexylethanolamine is used as an additive in lubricants to improve their performance, providing better protection and efficiency for machinery.
Used in Personal Care Products:
It is utilized as a pH buffer in personal care products, ensuring the stability and effectiveness of these formulations.
Used in Polymerization Reactions:
N-Cyclohexylethanolamine acts as a catalyst in polymerization reactions, facilitating the process and improving the outcome of the polymers produced.
Used in Agricultural Chemicals Synthesis:
N-CYCLOHEXYLETHANOLAMINE is employed in the synthesis of agricultural chemicals, contributing to the development of effective products for crop protection and enhancement.
Used in Pharmaceutical Production:
N-Cyclohexylethanolamine is also used in the production of pharmaceuticals, playing a role in the creation of various medicinal compounds.
While N-Cyclohexylethanolamine offers numerous benefits, it is essential to consider its potential chronic health effects and environmental impact, ensuring responsible and safe usage in all applications.

InChI:InChI=1/C8H17NO/c10-7-6-9-8-4-2-1-3-5-8/h8-10H,1-7H2

Upstream product

• 75-21-8 oxirane 
• 108-91-8 cyclohexylamine 
• 2216-92-4 N-phenylglycine ethyl ester 
• 108-94-1 cyclohexanone 
• 141-43-5 ethanolamine 
• 107-07-3 2-chloro-ethanol 
• 122-98-5 2-Anilinoethanol 
• 177-04-8 1-oxa-4-azaspiro[4.5]decane 
• 27110-20-9 4-Cyclohexyl-1-oxa-4-aza-spiro[4.5]decane 
• 155052-20-3 4-Aza-2-oxo-1-oxaspiro<5.4>dec-3-ene 4-oxide 
• 54961-36-3 1-(2-hydroxy-ethylamino)-cyclohexanecarbonitrile 
• 64-17-5 ethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 1586805-14-2 C₁₂H₂₃NO 

Downstream Products

• 55390-61-9 3-cyclohexyl-oxazolidin-2-one 
• 2842-41-3 2-(cyclohexyl-methyl-amino)-ethanol 
• 21461-57-4 2-(ethyl-cyclohexyl-amino)-ethanol 
• 19982-04-8 N,N'-dicyclohexylpiperazine 
• 108-93-0 cyclohexanol 
• 84977-55-9 benzoic acid-(2-cyclohexylamino-ethyl ester) 
• 32019-81-1 4-nitro-benzoic acid-[cyclohexyl-(2-hydroxy-ethyl)-amide] 
• 43196-37-8 N-(2-hydroxy-ethyl)-N-cyclohexyl-trans-cinnamamide 
• 73732-01-1 N-cyclohexyl-β-vinyloxyethylamine 
• 67992-31-8 N-Cyclohexyl-N-(2-hydroxyethyl)-aminoessigsaeure 
• 67992-35-2 4-cyclohexyl-2,3-epoxy-morpholine 

Relevant academic research and scientific papers

Indirect monoalkylation of primary and secondary amines by reductive decyanation of α-aminonitriles with sodium cyanoborohydride-mercury bis(trifluoroacetate)

Secondary and tertiary amines are prepared from α-aminonitriles by selective reductive cleavage of the cyanide moiety. The α-aminonitriles in this case, function as 'masked' imine or iminium ions and are 'unmasked' by mercury(II) in the presence of sodium cyanoborohydride to obtain the reduced product. Secondary amines may be prepared indirectly from primary amines in good yield without danger of over alkylation.

LIPID NANOPARTICLE COMPOSITION

Provided herein are lipids that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination.

Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors

A series of novel hydroxyethylaminomethylbenzimidazole analogs 5a-y were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, 2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino)butan-1-ol (5e, 94.3% inhibition at 30 μM, IC50 = 3.5 μM, cLogP = 4.132) and 3-cyclohexyl-2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino) propan-1-ol (5k, 94.7% inhibition at 30 μM, IC50 = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR (Fig. 5) indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon play an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of 5e and 5k with normal B lymphoblasts revealed that they had no significant effects on cell viability.

N-Alkylation of Alkylolamines with Alcohols Over Mesoporous Solid Acid–Base Cs–B–Zr Catalyst

Abstract: The mesoporous solid acid–base Cs–B–Zr mixed oxides were synthesized using the co-precipitation method followed by a subsequent thermal treatment. The catalytic activity of solid Cs–B–Zr mixed oxide was tested for solvent free acid–base catalysed direct alkylolamines with alcohols as green alkylating agent. The effects of Cs/B/Zr ratio, calcination temperature, reaction conditions, and reaction substrate on the catalytic performance of the catalysts were investigated. The XRD, N2 adsorption–desorption, ICP-OES, FT-IR and NH3/CO2-TPD results showed that the mesoporous structure and acid–base properties of the catalysts play important roles in the reaction. A suitable number of acid and basic sites on the catalyst lead to a high activity for the N-alkylation reaction. Graphical Abstract: A direct N-alkylation of amino alcohol with alcohols has been developed using mixed oxide Cs–B–Zr as an acid–base bifunctionalized catalyst.[Figure not available: see fulltext.]

Synthesis of pyrrole N-derivatives from oxazolidines

Transformations of oxazolidine derivatives synthesized from industrially produced amino alcohols, aldehydes, and ketones under basic or acidic catalysis lead to the formation of N-alkyl- and N-(hydroxyalkyl)-substituted pyrroles in 19-81% yields.

Efficient preparation of secondary aminoalcohols through a Ti(IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β-N-[hydroxyalkyl]aminosteroid derivatives

An efficient method for the synthesis of various secondary aminoalcohols through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3β-N-[hydroxyalkyl]aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds showed moderate to excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with Minimum Inhibitory Concentrations (MICs) varying from 3.12 to 25 μg/mL. No significant antibacterial activities are encountered against Gram-negative bacteria.

Synthesis of β-amino alcohols from aromatic amines and alkylene carbonates using Na-Y zeolite catalyst

A simple, efficient, and environmentally benign methodology for the synthesis of β-amino alcohols from aromatic amines and alkylene carbonates in the presence of the highly active and reusable solid base catalyst Na-Y zeolite is demonstrated. Georg Thieme Verlag Stuttgart.

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

Acid-catalyzed decomposition of cyclohexanespiro-2-oxazolidine

Heating cyclohexanespiro-2-oxazolidine at 160-200°C in the presence of protic acids results in its decomposition to give N-(2-hydroxyethyl)cyclohexylamine, N-(2-hydroxyethyl)-4,5,6,7-tetrahydroindole, and 2-cyclohexylidenecyclohexanone. The possible pathways leading to these compounds are discussed.

A New Synthesis of Highly Functional Nitrones through a Nitrosoketene Intermediate and Their Use for the Stereoselective Synthesis of Amino Acids

Reaction of 5-isonitroso-2,2-dimethyl-1,3-dioxane-4,6-dione with various ketones under reflux in toluene gives 3-oxazolin-5-one 3-oxides (cyclic nitrones) via a nitrosoketene intermediate generated from the isonitroso derivative.The cyclic nitrones can be used for the stereoselective dipolar cycloaddition to electron-rich olefins under high pressure to produce fused isoxazolidines.These isoxazolidines, in turn, are versatile intermediates for the stereoselective preparation of substituted α-amino acids.