N-Cyclohexylethanolamine

Base Information

• Chemical Name: N-Cyclohexylethanolamine
• CAS No.: 2842-38-8
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Hs Code.: 2922199090
• European Community (EC) Number: 220-636-4
• NSC Number: 1505
• UNII: F723W4Z785
• DSSTox Substance ID: DTXSID00182633
• Nikkaji Number: J34.790F
• Wikidata: Q83053342
• ChEMBL ID: CHEMBL4528441
• Mol file: 2842-38-8.mol

Synonyms:N-Cyclohexylethanolamine;2842-38-8;2-(CYCLOHEXYLAMINO)ETHANOL;Ethanol, 2-(cyclohexylamino)-;Abbomeen E-25 aerosol;Cyclohexlaminoethanol;Abromeen E-25;N-(2-Hydroxyethyl)cyclohexylamine;2-Cyclohexylaminoethanol;2-(cyclohexylamino)ethan-1-ol;Cyclohexylamine, hydroxyethyl-;N-(2-Hydroxyethyl) cyclohexylamine;NSC 1505;N-Hydroxyethylcyclohexylamine;Ethanol, 2-(cyclohexylamino)-, (aerosol);N-Cyclohexylaminoethanol;N-(Cyclohexylamino)ethanol (VAN);EINECS 220-636-4;BRN 1071413;NSC-1505;F723W4Z785;Ethanol, (aerosol);N-(Cyclohexylamino)ethanol;WLN: L6TJ AM2Q;Ethanol,2-(cyclohexylamino)-;SCHEMBL131659;CHEMBL4528441;N-Cyclohexyl-2-hydroxyethylamine;UNII-F723W4Z785;MGUMZJAQENFQKN-UHFFFAOYSA-;DTXSID00182633;NSC1505;MFCD00021326;N-(2-Hydroxyethyl)-N-cyclohexylamine;N-cyclohexyl-N-(2-hydroxyethyl)amine;AKOS000121422;GS-5424;SB83853;BP-10467;LS-66622;C1082;FT-0608763;EN300-18800;D95373;J-017065;Z90504557;F2190-0353

Chemical Property of N-Cyclohexylethanolamine

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Melting Point: 36°C
• Refractive Index: 1.4614 (estimate)
• Boiling Point: 115-118°C 10mm
• Flash Point: 117.6 °C
• PSA: 32.26000
• Density: 0.96 g/cm³
• LogP: 1.29190
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: almost transparency
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 79.3

Purity/Quality:

99% ^*data from raw suppliers

N-Cyclohexylethanolamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)NCCO

Technology Process of N-Cyclohexylethanolamine

There total 22 articles about N-Cyclohexylethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C12H23NO (1586805-14-2) → cyclohexyl(2-(hydroxy)ethyl)amine (2842-38-8) + 1-cyclohexyl-3-ethylpyrrole (1586805-22-2) + butan-1-ol (71-36-3)

Guidance literature:

With potassium hydroxide; Reflux;

DOI:10.1134/S1070428014020134

Reference yield: 52.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + ethanolamine (141-43-5) → cyclohexyl(2-(hydroxy)ethyl)amine (2842-38-8)

Guidance literature:

cyclohexanone; ethanolamine; With titanium(IV) isopropylate; In methanol; at 20 ℃; for 5h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2h;

Reference yield: 44.0%

1-oxa-4-azaspiro[4.5]decane (177-04-8) + ethanolamine (141-43-5) → cyclohexyl(2-(hydroxy)ethyl)amine (2842-38-8) + N-(2-hydroxyethyl)-4,5,6,7-tetrahydro-1H-indole (51265-34-0)

Guidance literature:

With polyphosphoric acid; for 10h; Reflux;

DOI:10.1134/S1070428014020134

upstream raw materials:

oxirane

cyclohexylamine

N-phenylglycine ethyl ester

cyclohexanone

Downstream raw materials:

3-cyclohexyl-oxazolidin-2-one

2-(cyclohexyl-methyl-amino)-ethanol

2-(ethyl-cyclohexyl-amino)-ethanol

N,N'-dicyclohexylpiperazine

Refernces

• 1、 -. "LIPID NANOPARTICLE COMPOSITION". Paragraph 00378. . Retrieved 2021/10/15.
• 2、 Chen, Aimin,Wang, Houyong,Liu, Rui,Bo, Yingying,Hu, Jun. "N-Alkylation of Alkylolamines with Alcohols Over Mesoporous Solid Acid–Base Cs–B–Zr Catalyst". . p. 1182 - 1193. Retrieved 2016/07/06.