N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

Base Information

Chemical Name:N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide
CAS No.:1083429-59-7
Molecular Formula:C₃₃H₃₂F₃N₇O₄
Molecular Weight:647.657
Hs Code.:

Synonyms:N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

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Chemical Property of N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

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Technology Process of N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

There total 9 articles about N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1083428-92-5
5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

: 7470-38-4
4-morpholin-4-yl-benzoic acid

: 1083429-59-7
N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1083429-59-7
N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8 h / 115 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane; water / 3 h / 20 °C / Acidic aqueous solution

3.2: 0.17 h / 0 - 5 °C / Alkaline aqueous solution

4.1: triethylamine; HATU / dichloromethane / 1 h / 20 °C

With potassium acetate; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 14793-00-1
6-chloro-2-methylimidazo-<1,2-b>pyridazine

: 1083429-59-7
N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 0.75 h / 110 °C / Microwave irradiation

2.1: potassium carbonate / ISOPROPYLAMIDE / 8 h / 100 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 0 - 5 °C

4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane; water / 3 h / 20 °C / Acidic aqueous solution

5.2: 0.17 h / 0 - 5 °C / Alkaline aqueous solution

6.1: triethylamine; HATU / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;