5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Base Information

Chemical Name:5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine
CAS No.:1083428-92-5
Molecular Formula:C₂₂H₂₁F₃N₆O₂
Molecular Weight:458.443
Hs Code.:

Synonyms:5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Suppliers and Price of 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

There total 8 articles about 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083429-84-8
(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester

: 1083428-92-5
5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: (2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-carbamic acid tert-butylester; With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 3h; Acidic aqueous solution;

With ammonia; In ethanol; dichloromethane; water; at 0 - 5 ℃; for 0.166667h; Alkaline aqueous solution;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1083428-92-5
5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8 h / 115 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane; water / 3 h / 20 °C / Acidic aqueous solution

3.2: 0.17 h / 0 - 5 °C / Alkaline aqueous solution

With potassium acetate; potassium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 947249-01-6
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3-trifluoromethyl-pyridin-2-ylamine

: 1083428-92-5
5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.5 h / 150 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane; water / 3 h / 20 °C / Acidic aqueous solution

2.2: 0.17 h / 0 - 5 °C / Alkaline aqueous solution

With potassium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; ISOPROPYLAMIDE; water;