N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide

Base Information

• Chemical Name: N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide
• CAS No.: 1350717-72-4
• Molecular Formula: C₁₉H₁₅ClN₂O₂
• Molecular Weight: 338.793
• Mol file: 1350717-72-4.mol

Synonyms:N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide

Chemical Property of N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide

There total 4 articles about N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

oxalyl dichloride (79-37-8) + N-(5-chloro-2-methylphenyl)succinamic acid (405923-83-3) + 1-amino-naphthalene (134-32-7) → N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide (1350717-72-4)

Guidance literature:

oxalyl dichloride; N-(5-chloro-2-methylphenyl)succinamic acid; In 1,4-dioxane; at 0 - 20 ℃; for 2.5h;

1-amino-naphthalene; With pyridine; In 1,4-dioxane; at 0 - 20 ℃; for 24.5h;

With water; sodium hydrogencarbonate; In 1,4-dioxane; Saturated solution;

DOI:10.1016/j.bmc.2011.06.086

Reference yield:

oxalyl dichloride (79-37-8) + 4-(naphthalene-1-ylamino)-4-oxo-butanoic acid (37642-93-6) + 5-chloro-2-methyl-benzenamine (95-79-4) → N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide (1350717-72-4)

Guidance literature:

oxalyl dichloride; 4-(naphthalene-1-ylamino)-4-oxo-butanoic acid; In 1,4-dioxane; at 0 - 20 ℃; for 2.5h;

5-chloro-2-methyl-benzenamine; With pyridine; In 1,4-dioxane; at 0 - 20 ℃; for 24.5h;

With water; sodium hydrogencarbonate; In 1,4-dioxane; Saturated solution;

DOI:10.1016/j.bmc.2011.06.086

Reference yield:

5-chloro-2-methyl-benzenamine (95-79-4) → N-(5-chloro-2-methyl-phenyl)-N'-(naphthalen-1-yl)oxalamide (1350717-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 24 h / Reflux

2.1: 1,4-dioxane / 2.5 h / 0 - 20 °C

2.2: 24.5 h / 0 - 20 °C

2.3: Saturated solution

In 1,4-dioxane;

DOI:10.1016/j.bmc.2011.06.086

upstream raw materials:

oxalyl dichloride

N-(5-chloro-2-methylphenyl)succinamic acid

1-amino-naphthalene

4-(naphthalene-1-ylamino)-4-oxo-butanoic acid

Refernces