(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

Base Information

Chemical Name:(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane
CAS No.:252961-61-8
Molecular Formula:C₂₃H₂₆O₂
Molecular Weight:334.458
Hs Code.:

Synonyms:(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

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Chemical Property of (1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

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Technology Process of (1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

There total 6 articles about (1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-39-0
benzyl bromide

: 252961-66-3
(1S,2R,4S,6S)-4-Isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptan-2-ol

: 252961-61-8
(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)01623-8

Reference yield:

: 2244-16-8,6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 252961-61-8
(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / tetrahydrofuran

2: 79 percent / PCC / CH₂Cl₂

3: 62 percent / Triton B; H₂O₂ / H₂O / 6 h / 60 °C

4: 75 percent / Li(t-BuO)3AlH / tetrahydrofuran

5: 96 percent / NaH / dimethylformamide

With dihydrogen peroxide; N-benzyl-trimethylammonium hydroxide; sodium hydride; lithium tri-t-butoxyaluminum hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Phenylation / 2: Oxidation / 3: Epoxidation / 4: Reduction / 5: Alkylation;
DOI:10.1016/S0040-4039(99)01623-8

Reference yield:

: 132610-89-0
(-)-(R)-2-methyl-5-isopropenyl-3-phenylcyclohex-2-en-1-one

: 252961-61-8
(1S,2R,4S,6S)-2-Benzyloxy-4-isopropenyl-1-methyl-6-phenyl-7-oxa-bicyclo[4.1.0]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Triton B; H₂O₂ / H₂O / 6 h / 60 °C

2: 75 percent / Li(t-BuO)3AlH / tetrahydrofuran

3: 96 percent / NaH / dimethylformamide

With dihydrogen peroxide; N-benzyl-trimethylammonium hydroxide; sodium hydride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Epoxidation / 2: Reduction / 3: Alkylation;
DOI:10.1016/S0040-4039(99)01623-8