(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

Base Information

Chemical Name:(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride
CAS No.:1539262-89-9
Molecular Formula:C₂₂H₃₁NO₂*ClH
Molecular Weight:377.955
Hs Code.:

Synonyms:(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

Chemical Property:

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Technology Process of (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

There total 12 articles about (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1539221-44-7
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenol

: 1539262-89-9
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

Guidance literature:: With hydrogenchloride; In water; acetonitrile; at 50 ℃; for 1.5h; pH=2 - 2.5;

Reference yield:

: 250214-40-5
(R,S)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

: 1539262-89-9
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; pyridine / 20 - 60 °C

2: (S)-Mandelic acid / tert-Amyl alcohol / 70 °C

3: hydrogenchloride / water; acetonitrile / 1.5 h / 50 °C / pH 2 - 2.5

With hydrogenchloride; (S)-Mandelic acid; In pyridine; tert-Amyl alcohol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1539220-70-6
3-(2-hydroxy-5-(hydroxymethyl)phenyl)-N,N-diisopropyl-3-phenylacrylamide

: 1539262-89-9
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 5%-palladium/activated carbon; hydrogen; sodium carbonate / 2-methyltetrahydrofuran; ethanol / 50 °C / 750.08 Torr / Inert atmosphere

2: 5%-palladium/activated carbon; hydrogen; sodium carbonate / water; toluene / 50 - 55 °C / 750.08 Torr / Inert atmosphere

3: Vitride^? / toluene / 5 - 25 °C / Inert atmosphere; Cooling with ice

4: (S)-Mandelic acid / tert-Amyl alcohol / 70 °C

5: hydrogenchloride / water; acetonitrile / 1.5 h / 50 °C / pH 2 - 2.5

With hydrogenchloride; 5%-palladium/activated carbon; (S)-Mandelic acid; hydrogen; sodium carbonate; In 2-methyltetrahydrofuran; tert-Amyl alcohol; ethanol; water; toluene; acetonitrile;