(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Base Information

Chemical Name:(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one
CAS No.:94944-08-8
Molecular Formula:C₂₅H₃₃NO₄Si
Molecular Weight:439.627
Hs Code.:

Synonyms:(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

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Chemical Property of (3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of (3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

There total 4 articles about (3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 94944-07-7
(3S,4S,1'R) N-p-methoxyphenyl-3-(1'-hydroxyethyl)-4-benzoylazetidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 94944-08-8
(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/ja00291a069

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 94944-06-6
(2R,3R)-N-(benzoyl)methyl-N-4-methoxyphenyl-2,3-epoxybutanamide

: 94944-08-8
(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: (2R,3R)-N-(benzoyl)methyl-N-4-methoxyphenyl-2,3-epoxybutanamide; In tetrahydrofuran; at 60 ℃; for 2h;

tert-butyldimethylsilyl chloride; With tetrazolium; triethylamine; In toluene; at 80 ℃; for 10h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 20 ℃; for 10h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 94944-06-6
(2R,3R)-N-(benzoyl)methyl-N-4-methoxyphenyl-2,3-epoxybutanamide

: C₂₅H₃₃NO₄Si

: 94944-08-8
(3S,4S)-4-Benzoyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: (2R,3R)-N-(benzoyl)methyl-N-4-methoxyphenyl-2,3-epoxybutanamide; In tetrahydrofuran; at 60 ℃; for 2h;

tert-butyldimethylsilyl chloride; With tetrazolium; triethylamine; In toluene; at 80 ℃; for 10h;