(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Base Information

Chemical Name:(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone
CAS No.:1442445-16-0
Molecular Formula:C₂₆H₂₇ClF₃N₅O
Molecular Weight:517.981
Hs Code.:

Synonyms:(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

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Chemical Property of (4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

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Technology Process of (4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

There total 10 articles about (4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442445-76-2
C₃₁H₃₅ClF₃N₅O₃

: 1442445-16-0
(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1442445-64-8
(R)-5-bromo-N-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)benzene-1,2-diamine

: 1442445-16-0
(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium nitrite / 18 h / 20 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium nitrite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1442445-65-9
(R)-6-bromo-1-(1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazole

: 1442445-16-0
(4-(1-((R)-1-(4-chloro-2-(trifluoromethyl)phenyl)ethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-5,6-dihydropyridin-1(2H)-yl)((R)-piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;