4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Base Information

Chemical Name:4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile
CAS No.:1598417-11-8
Molecular Formula:C₂₇H₃₁N₅O₃
Molecular Weight:473.575
Hs Code.:

Synonyms:4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

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Chemical Property of 4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Chemical Property:

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Technology Process of 4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

There total 12 articles about 4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872714-54-0
4-ethenyl-6-(methyloxy)-3-quinolinecarbonitrile

: (2,5-dimethyl-3-nitro-benzyl)-piperidin-4-yl-amine hydrochloride

: 1598417-11-8
4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 27023-01-4
2,5-dimethyl-3-nitro-benzoic acid methyl ester

: 1598417-11-8
4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C

2.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 - 20 °C

4.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; diisobutylaluminium hydride; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13730-55-7
methyl 2,5-dimethylbenzoate

: 1598417-11-8
4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 0.33 h / 0 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C

3.1: titanium(IV) isopropylate / ethanol / 0 - 20 °C

3.2: 3 h / 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 0 - 20 °C

5.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 3 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; sulfuric acid; nitric acid; diisobutylaluminium hydride; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;