2,5-Dimethyl-3-nitrobenzaldehyde

Base Information

• Chemical Name: 2,5-Dimethyl-3-nitrobenzaldehyde
• CAS No.: 69022-52-2
• Molecular Formula: C9H9 N O3
• Molecular Weight: 179.17
• Hs Code.: 2913000090
• Mol file: 69022-52-2.mol

Synonyms:2,5-Dimethyl-3-nitrobenzaldehyde

Chemical Property of 2,5-Dimethyl-3-nitrobenzaldehyde

Chemical Property:

• PSA: 62.89000
• LogP: 2.54730

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dimethyl-3-nitrobenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dimethyl-3-nitrobenzaldehyde

There total 5 articles about 2,5-Dimethyl-3-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

→ dimethyl-2,5 nitro-3 benzaldehyde (69022-52-2)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 53.0%

1-(chloromethyl)-2,5-dimethyl-3-nitrobenzene (18102-22-2) → dimethyl-2,5 nitro-3 benzaldehyde (69022-52-2)

Guidance literature:

With hydrogenchloride; hexamethylenetetramine; acetic acid; In water; for 2.5h; Heating;

DOI:10.1021/jo01299a028

Reference yield: 27.0%

chlorosulfonic acid (7790-94-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + mononitro-p-xylene (89-58-7) → 2,5-dimethyl-4-nitrobenzaldehyde (1202389-18-1) + dimethyl-2,5 nitro-3 benzaldehyde (69022-52-2)

Guidance literature:

chlorosulfonic acid; formaldehyd; mononitro-p-xylene; With sodium chloride; at 10 - 20 ℃; for 16h;

With hexamethylenetetramine; acetic acid; In water; for 2h; Reflux;

With hydrogenchloride; In water; for 0.333333h; Overall yield = 35 %; Overall yield = 4.2 g; Reflux;

DOI:10.1039/c5ob02482j

upstream raw materials:

1-(chloromethyl)-2,5-dimethyl-3-nitrobenzene

hexamethylenetetramine

methyl 2,5-dimethylbenzoate

chlorosulfonic acid

Downstream raw materials:

trans-2,5-dimethyl-3-nitrocinnamic acid

4-(2,5-dimethyl-3-nitro-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester

4-(2-(4-(2,5-dimethyl-3-nitrobenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

3-acetamido-2,5-dimethylcinnamoyl azide

Refernces

• 1、 Gotham, Victoria J. B.,Hobbs, Melanie C.,Burgin, Ryan,Turton, David,Smythe, Carl,Coldham, Iain. "Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay". supporting information. p. 1559 - 1563. Retrieved 2016/02/10.
• 2、 -. "4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use". . . Retrieved 2008/06/13.