(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

Base Information

Chemical Name:(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate
CAS No.:1012057-57-6
Molecular Formula:C₂₇H₂₃ClFN₃O₅
Molecular Weight:523.948
Hs Code.:

Synonyms:(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

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Chemical Property of (E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

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Technology Process of (E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

There total 8 articles about (E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1012057-56-5
(E)-methyl 3-(4-(2-(tosyloxy)ethoxy)phenyl)acrylate

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1012057-57-6
(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1012057-57-6
(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 3 h / Heating / reflux

2: methanol; lithium hydroxide; water / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

With methanol; lithium hydroxide; water; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-52-9
6-hydroxy-7-methoxyquinazolin-4(3H)-one

: 1012057-57-6
(E)-methyl 3-(4-(2-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)ethoxy)phenyl) acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 3 h / Heating / reflux

2: trichlorophosphate / 3 h / Heating / reflux

3: isopropyl alcohol / 3 h / Heating / reflux

4: methanol; lithium hydroxide; water / 0.5 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C

With pyridine; methanol; lithium hydroxide; water; potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol;