methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate

Base Information

• Chemical Name: methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate
• CAS No.: 115047-83-1
• Molecular Formula: C₁₆H₂₂NO₆P
• Molecular Weight: 355.328

Synonyms:methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate

Chemical Property of methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate

Chemical Property:

Purity/Quality:

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Technology Process of methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate

There total 2 articles about methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanolic sodium methoxide + aqueous formaldehyde (formalin) + trimethyl 2-phosphonoacrylate (55168-74-6) → Methyl-(1-carbobenzyloxyaminoethyl)-(2-carbomethoxy-2-propenyl)-phosphinate (113592-59-9,113592-65-7,115047-83-1)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + trimethyl 2-phosphonoacrylate (55168-74-6) + methyl <1-(S)-<(benzyloxycarbonyl)amino>ethyl>phosphinate (113592-51-1) → methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate (115047-83-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00117a017

Reference yield: 82.0%

methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate (115047-83-1) → <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinic acid (115047-84-2)

Guidance literature:

With lithium iodide; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1021/jm00117a017

upstream raw materials:

trimethyl 2-phosphonoacrylate

formaldehyd

methyl <1-(S)-<(benzyloxycarbonyl)amino>ethyl>phosphinate

Downstream raw materials:

<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinic acid

<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

benzyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinate

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