N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 1379667-14-7
• Molecular Formula: C₁₉H₁₈N₂O₃S
• Molecular Weight: 354.43
• Mol file: 1379667-14-7.mol

Synonyms:N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide

There total 3 articles about N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-toluenesulfonyl azide (941-55-9) + 2-(4-hydroxymethylphenyl)pyridine (98061-39-3) → N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide (1379667-14-7)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In 1,2-dichloro-ethane; at 80 ℃; for 48h;

DOI:10.1021/ja303527m

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide (1379667-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / water; acetone / 0 - 20 °C

2: silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer / 1,2-dichloro-ethane / 48 h / 80 °C

With silver hexafluoroantimonate; sodium azide; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In water; 1,2-dichloro-ethane; acetone;

DOI:10.1021/ja303527m

Reference yield:

2-bromo-pyridine (109-04-6) + p-hydroxymethylphenylboronic acid (59016-93-2) → N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide (1379667-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 12 h / Inert atmosphere; Reflux

2: silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer / 1,2-dichloro-ethane / 48 h / 80 °C

With silver hexafluoroantimonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium carbonate; In ethanol; water; 1,2-dichloro-ethane; toluene;

DOI:10.1021/ja303527m

upstream raw materials:

2-bromo-pyridine

p-hydroxymethylphenylboronic acid

4-toluenesulfonyl azide

2-(4-hydroxymethylphenyl)pyridine