(4-(Pyridin-2-YL)phenyl)methanol

Base Information

• Chemical Name: (4-(Pyridin-2-YL)phenyl)methanol
• CAS No.: 98061-39-3
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30363913
• Nikkaji Number: J3.482.872E
• Wikidata: Q72485520
• Mol file: 98061-39-3.mol

Synonyms:98061-39-3;(4-(PYRIDIN-2-YL)PHENYL)METHANOL;2-(4-Hydroxymethylphenyl)pyridine;(4-pyrid-2-ylphenyl)methanol;(4-pyridin-2-ylphenyl)methanol;[4-(pyridin-2-yl)phenyl]methanol;4-(Pyridin-2-yl)benzyl alcohol;(4-Pyridin-2-yl-phenyl)-methanol;4-(2-pyridyl)benzyl alcohol;4-(2-Pyridinyl)benzylalcohol;SCHEMBL533591;4-(2-pyridinyl)benzyl alcohol;4-(Pyrid-2-yl)benzyl alcohol;DTXSID30363913;AMY33148;MFCD04116292;AKOS006345716;SB52706;AS-44216;CS-0210267;FT-0674208;EN300-2598526;J-501325

Chemical Property of (4-(Pyridin-2-YL)phenyl)methanol

Chemical Property:

• Vapor Pressure: 1.29E-05mmHg at 25°C
• Melting Point: 49 °C
• Refractive Index: 1.6
• Boiling Point: 353.8 °C at 760 mmHg
• PKA: 14.21±0.10(Predicted)
• Flash Point: 167.8 °C
• PSA: 33.12000
• Density: 1.145 g/cm³
• LogP: 2.24090
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 185.084063974
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Pyridinyl)benzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CC=C(C=C2)CO
• Uses: A phenylpyridine derivative, 2-(4-Hydroxymethylphenyl)pyridine can be used in the preparation of metal complexes as well as an intermediate in organic synthesis. A phenylpyridine derivative used in the preparation of metal complexes as well as an intermediate in organic synthesis.

Technology Process of (4-(Pyridin-2-YL)phenyl)methanol

There total 12 articles about (4-(Pyridin-2-YL)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2'-pyridyl)benzaldehyde (127406-56-8) → 2-(4-hydroxymethylphenyl)pyridine (98061-39-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1021/jo0614341

Reference yield: 93.0%

2-chloropyridine (109-09-1) + p-hydroxymethylphenylboronic acid (59016-93-2) → 2-(4-hydroxymethylphenyl)pyridine (98061-39-3)

Guidance literature:

With C₃₇H₄₄ClN₂O₃PPd; caesium carbonate; In water; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1007/s11243-016-0036-5

Reference yield: 88.0%

pyridin-2-ylboronic acid (197958-29-5) + para-Chlorobenzyl alcohol (873-76-7) → 2-(4-hydroxymethylphenyl)pyridine (98061-39-3)

Guidance literature:

With C₃₈H₃₇ClN₄O₂Pd; potassium carbonate; In butan-1-ol; at 100 ℃; for 36h; Inert atmosphere; Schlenk technique;

upstream raw materials:

2-iodopyridine

benzyl alcohol

4-pyridin-2-yl-benzoic acid methyl ester

4-(2'-pyridyl)benzaldehyde

Downstream raw materials:

2-(4-methylphenyl)pyridine

C₈₁H₅₇N₅O₃

N-[5-hydroxymethyl-2-(pyridin-2-yl)phenyl]-4-methylbenzenesulfonamide

tert-butyl [5-(hydroxymethyl)-2-(pyridin-2-yl)phenyl]carbamate

Refernces

• 1、 Pfund, Bj?rn,Steffen, Debora M.,Schreier, Mirjam R.,Bertrams, Maria-Sophie,Ye, Chen,B?rjesson, Karl,Wenger, Oliver S.,Kerzig, Christoph. "UV Light Generation and Challenging Photoreactions Enabled by Upconversion in Water". supporting information. p. 10468 - 10476. Retrieved 2020/07/27.
• 2、 Zhang, Guo-Fu,Li, Yue,Xie, Xiao-Qiang,Ding, Cheng-Rong. "Ru-Catalyzed Regioselective Direct Hydroxymethylation of (Hetero)Arenes via C-H Activation". supporting information. p. 1216 - 1219. Retrieved 2017/03/14.