ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

Base Information

Chemical Name:ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate
CAS No.:1510829-97-6
Molecular Formula:C₁₄H₁₃ClF₃NO₃
Molecular Weight:335.71
Hs Code.:

Synonyms:ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

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Chemical Property of ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

There total 1 articles about ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189352-83-7
1-chloro-3-iodo-5-(trifluoromethyl)benzene

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 1510829-97-6
ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 40 ℃; Inert atmosphere;

Reference yield:

: 1510829-97-6
ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

: (2R)-ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In 2-methyltetrahydrofuran; n-heptane; at -45 - -35 ℃; Inert atmosphere;

Reference yield:

: 1510829-97-6
ethyl 1-(3-chloro-5-(trifluoromethyl)phenyl)-5-oxopyrrolidine-2-carboxylate

: 1510832-36-6
C₂₁H₂₃ClF₄N₆O₂

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / 2-methyltetrahydrofuran; n-heptane / -45 - -35 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dimethyl sulfoxide / 2 h / 50 °C

3: ethanol / 75 °C

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In 2-methyltetrahydrofuran; ethanol; n-heptane; dimethyl sulfoxide;