N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

Base Information

Chemical Name:N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide
CAS No.:1620147-11-6
Molecular Formula:C₂₈H₂₃F₃N₆O₂
Molecular Weight:532.525
Hs Code.:

Synonyms:N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

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Chemical Property of N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

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Technology Process of N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

There total 12 articles about N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1620147-07-0
N-(2,6-dimethylphenyl)-4-(6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

: 74-88-4
methyl iodide

: 1620147-11-6
N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 1620146-98-6
2-chloro-9-(4-methoxybenzyl)-6-(4-(trifluoromethoxy)phenyl)-9H-purine

: 1620147-11-6
N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

2: trifluoroacetic acid / 4 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 115204-74-5
2,6-dichloro-9-(4-methoxyphenylmethyl)-9H-purine

: 1620147-11-6
N-(2,6-dimethylphenyl)-4-(9-methyl-6-(4-(trifluoromethoxy)phenyl)-9H-purin-2-ylamino)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

3: trifluoroacetic acid / 4 h / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.066