(S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

Base Information

Chemical Name:(S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one
CAS No.:1215291-39-6
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:(S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

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Chemical Property of (S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

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Technology Process of (S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

There total 2 articles about (S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1215291-47-6
(S)-4-(1-methylethyl)-3-(3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

: 74-88-4
methyl iodide

: 1215291-39-6
(S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

Guidance literature:: (S)-4-(1-methylethyl)-3-(3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -76 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -76 - -25 ℃; for 4h; Inert atmosphere;

With water; acetic acid; In tetrahydrofuran; hexane; at -25 - 20 ℃;
DOI:10.1002/hlca.200900385

Reference yield: 40.0%

: 1215291-23-8
(S)-4-(1-methylethyl)-3-[(E)-3-nitroprop-2-enoyl]-5,5-diphenyloxazolidin-2-one

: 75-16-1
methylmagnesium bromide

: (S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

: 1215291-39-6
(S)-4-(1-methylethyl)-3-(2-methyl-3-nitropropanoyl)-5,5-diphenyloxazolidin-2-one

Guidance literature:: methylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; at -40 ℃; for 0.166667h; Inert atmosphere;

(S)-4-(1-methylethyl)-3-[(E)-3-nitroprop-2-enoyl]-5,5-diphenyloxazolidin-2-one; In tetrahydrofuran; diethyl ether; at -70 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/hlca.200900385