(1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate

Base Information

• Chemical Name: (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate
• CAS No.: 88292-44-8
• Molecular Formula: C₂₅H₃₂O₃
• Molecular Weight: 380.527
• Mol file: 88292-44-8.mol

Synonyms:(1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate

Chemical Property of (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate

There total 6 articles about (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-8-phenylmenthol (65253-04-5) → (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate (88292-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / 4-dimethylaminopyridine / CH₂Cl₂ / 48 h

2: K₂CO₃ / methanol; H₂O / 72 h / Heating

With potassium carbonate; dicyclohexyl-carbodiimide; dmap; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)80228-3

Reference yield:

d,l-O-Acetylatrolactinsaeure (10487-92-0,23236-71-7,24318-49-8) → (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate (88292-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / 4-dimethylaminopyridine / CH₂Cl₂ / 48 h

2: K₂CO₃ / methanol; H₂O / 72 h / Heating

With potassium carbonate; dicyclohexyl-carbodiimide; dmap; In methanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)80228-3

Reference yield:

2-Acetoxy-2-phenyl-propionic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester → (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (R)-2-hydroxy-2-phenylpropanoate (88292-45-9) + (1'R,2'S,5'R)-2'-(1-methyl-1-phenylethyl)-5'-methylcyclohexyl (S)-2-hydroxy-2-phenylpropanoate (88292-44-8)

Guidance literature:

With potassium carbonate; In methanol; water; for 72h; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/S0040-4020(01)80228-3

upstream raw materials:

methyl magnesium iodide

Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester

methylmagnesium bromide

2-Oxopropansaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>ester

Downstream raw materials:

(2S)-2-phenylpropane-1,2-diol

8-Phenylmenthyl (S)-2-phenylpropionate

(-)-8-Phenylmenthyl (R)-2-phenylpropionate

2-Methyl-2-phenyl-pent-4-enoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester