3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Name:3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine
CAS No.:1260539-04-5
Molecular Formula:C₂₄H₂₅N₇O
Molecular Weight:427.509
Hs Code.:

Synonyms:3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

There total 6 articles about 3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1260539-02-3
4-iodo-3-isopropyl-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

: 4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole dihydrochloride

: 1260539-04-5
3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; In dimethyl sulfoxide; at 110 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b01085

Reference yield:

: 113975-22-7
2-fluoro-3-iodopyridine

: 1260539-04-5
3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.25 h / -78 °C

1.2: 1 h / -78 °C

1.3: 24 h / 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

2.2: 2.17 h / 0 - 20 °C / Inert atmosphere

3.1: 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; copper(I) oxide / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

With copper(I) oxide; n-butyllithium; 4,7-dimethoxy-1,10-phenanthroline; sodium hydride; caesium carbonate; diisopropylamine; In tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b01085

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1260539-04-5
3-isopropyl-1-(4-methoxybenzyl)-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: copper(I) oxide; caesium carbonate; 4,7-dimethoxy-1,10-phenanthroline / dimethyl sulfoxide / 24 h / 110 °C / Inert atmosphere

With copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; sodium hydride; caesium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c01715