benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate

Base Information

• Chemical Name: benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate
• CAS No.: 686276-33-5
• Molecular Formula: C₃₄H₃₅N₃O₅
• Molecular Weight: 565.669
• Mol file: 686276-33-5.mol

Synonyms:benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate

Chemical Property of benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate

There total 3 articles about benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid (132388-60-4,200625-96-3) → benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate (686276-33-5)

Guidance literature:

(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; for 3h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01880

Reference yield:

(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid (132388-60-4,200625-96-3) → benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate (686276-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methylmorpholine / CH₂Cl₂ / 0 °C

2: CH₂Cl₂ / 0 - 23 °C

With 4-methyl-morpholine; In dichloromethane;

DOI:10.1021/jm9800696

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + C37H38N2O7 → benzyl (S)-(1-(methoxy(methyl)amino)-1,5-dioxo-5-(tritylamino)pentan-2-yl)carbamate (686276-33-5)

Guidance literature:

In dichloromethane; at 0 - 23 ℃;

DOI:10.1021/jm9800696

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(S)-2-(((benzyloxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid

Downstream raw materials:

(E)-(S)-4-Benzyloxycarbonylamino-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester