Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

Base Information

Chemical Name:Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate
CAS No.:118111-87-8
Molecular Formula:C₄₆H₄₆N₄O₁₁
Molecular Weight:830.891
Hs Code.:

Diethyl N-<4-<N-<<2,4-bis<2-(benzoyloxy)ethoxy>-6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

Synonyms:Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

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Chemical Property of Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

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Technology Process of Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

There total 5 articles about Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 76858-72-5
diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

: 112888-67-2
C₂₇H₂₃BrN₂O₆

: 118111-87-8
Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 60 ℃; for 16h;
DOI:10.1021/jm00123a010

Reference yield:

: 98-88-4
benzoyl chloride

: 118111-87-8
Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / pyridine / 16 h / Ambient temperature

2: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

3: 15 percent / 2,6-lutidine / dimethylformamide / 16 h / 60 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010

Reference yield:

: 39576-82-4
6-methyl-2,4-dichloroquinazoline

: 118111-87-8
Diethyl N-<4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 2.) DMF, 100 deg C, 2 h

2: 36 percent / pyridine / 16 h / Ambient temperature

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

4: 15 percent / 2,6-lutidine / dimethylformamide / 16 h / 60 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; sodium hydride; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010