C₁₂H₁₃FO₃

Base Information

• Chemical Name: C₁₂H₁₃FO₃
• CAS No.: 1347047-03-3
• Molecular Formula: C₁₂H₁₃FO₃
• Molecular Weight: 224.232
• Mol file: 1347047-03-3.mol

Synonyms:C₁₂H₁₃FO₃

Chemical Property of C₁₂H₁₃FO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₂H₁₃FO₃

There total 4 articles about C₁₂H₁₃FO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

C13H13FO5 (1347047-01-1) → C11H10F2O2 (1347046-90-5) + C12H13FO3 (1347047-03-3)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; triethylamine tris(hydrogen fluoride); In tert-butyl methyl ether; at 25 ℃; for 12h; regioselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/jacs.9b07575

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → C11H10F2O2 (1347046-90-5) + C12H13FO3 (1347047-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / 4.17 h / 20 °C

2: pyridine; dmap / tetrahydrofuran; N,N-dimethyl-formamide / 10 h / 20 °C

3: bis(1,5-cyclooctadiene)diiridium(I) dichloride; α,α,α-trifluorotoluene; triethylamine tris(hydrogen fluoride) / diethyl ether / 12 h / 20 °C

With pyridine; dmap; bis(1,5-cyclooctadiene)diiridium(I) dichloride; α,α,α-trifluorotoluene; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/ja2087213

Reference yield:

C11H11FO3 (1347047-65-7) → C11H10F2O2 (1347046-90-5) + C12H13FO3 (1347047-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / tetrahydrofuran; N,N-dimethyl-formamide / 10 h / 20 °C

2: bis(1,5-cyclooctadiene)diiridium(I) dichloride; α,α,α-trifluorotoluene; triethylamine tris(hydrogen fluoride) / diethyl ether / 12 h / 20 °C

With pyridine; dmap; bis(1,5-cyclooctadiene)diiridium(I) dichloride; α,α,α-trifluorotoluene; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/ja2087213

upstream raw materials:

C₁₃H₁₃FO₅

C₁₁H₁₁FO₃

C₁₃H₁₁Cl₃FNO₃

4-fluorobenzoyl chloride