1347047-01-1Relevant articles and documents
Iridium-catalyzed allylic fluorination of trichloroacetimidates
Topczewski, Joseph J.,Tewson, Timothy J.,Nguyen, Hien M.
, p. 19318 - 19321 (2012/01/06)
A rapid allylic fluorination method utilizing trichloroacetimidates in conjunction with an iridium catalyst has been developed. The reaction is conducted at room temperature under ambient air and relies on Et 3N?3HF reagent to provide branched allylic fluorides with complete regioselectivity. This high-yielding reaction can be conducted on a multigram scale and shows considerable functional group tolerance. The use of [18F]KF?Kryptofix allowed 18F- incorporation in 10 min.