1-HYDROXY-2-CHLOROINDANE, TRANS ISOMER

Base Information

• Chemical Name: 1-HYDROXY-2-CHLOROINDANE, TRANS ISOMER
• CAS No.: 19598-10-8
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.623
• Mol file: 19598-10-8.mol

Synonyms:1-Indanol,2-chloro-, trans- (8CI); 1H-Inden-1-ol, 2-chloro-2,3-dihydro-, trans-

Chemical Property of 1-HYDROXY-2-CHLOROINDANE, TRANS ISOMER

Chemical Property:

• PSA: 20.23000
• LogP: 1.88350

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-HYDROXY-2-CHLOROINDANE, TRANS ISOMER

There total 16 articles about 1-HYDROXY-2-CHLOROINDANE, TRANS ISOMER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-indene (95-13-6) → trans-2-chloroindan-1-ol (19598-01-7,19598-10-8,67864-28-2,73951-59-4,88270-73-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; water; cetyltrimethylammonim bromide; sodium chloride; at 20 ℃; diastereoselective reaction;

DOI:10.1039/c1cc11685a

Reference yield: 23.0%

1-indene (95-13-6) → 1-hydroxy-2-indanone (109296-68-6) + cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5) + cis-2-chloroindan-1-ol (19598-01-7,19598-10-8,67864-28-2,73951-59-4,88270-73-9) + trans-2-chloroindan-1-ol (19598-01-7,19598-10-8,67864-28-2,73951-59-4,88270-73-9)

Guidance literature:

With chlorine dioxide; In water; for 1h; Further byproducts given; pH=4;

DOI:10.1016/S0040-4039(00)85380-0

Reference yield: 23.0%

1-indene (95-13-6) → 1-hydroxy-2-indanone (109296-68-6) + cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5) + cis-2-chloroindan-1-ol (19598-01-7,19598-10-8,67864-28-2,73951-59-4,88270-73-9) + trans-2-chloroindan-1-ol (19598-01-7,19598-10-8,67864-28-2,73951-59-4,88270-73-9)

Guidance literature:

With chlorine dioxide; In water; for 1h; Further byproducts given; pH=4;

DOI:10.1016/S0040-4039(00)85380-0

upstream raw materials:

1,2-dichloro-2,3-dihydro-1H-indene

1-indene

((1S,2S)-2-Chloro-indan-1-yloxymethylene)-dimethyl-ammonium; chloride

1,4-dioxane

Downstream raw materials:

trans-2-chloroindan-1-ol

2-indanone

1-indene

trans-indane-1,2-diol

Refernces

• 1、 Swamy, Peraka,Kumar, Macharla Arun,Reddy, Marri Mahender,Naresh, Mameda,Srujana, Kodumuri,Narender, Nama. "The vicinal functionalization of olefins: A facile route to the direct synthesis of β-chlorohydrins and β-chloroethers". . p. 26288 - 26294. Retrieved 2014/07/08.
• 2、 Rav-Acha, Chaim,Choshen, Ehud,Sarel, Shalom. "Chlorine Dioxide as an Electron-Transfer Oxidant of Olefins". . p. 1728 - 1733. Retrieved 2007/10/02.