methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate

Base Information

• Chemical Name: methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate
• CAS No.: 1195787-86-0
• Molecular Formula: C₃₁H₂₈F₇N₃O₃
• Molecular Weight: 623.57
• Mol file: 1195787-86-0.mol

Synonyms:methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate

Chemical Property of methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate

There total 5 articles about methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-aminopent-4-ynoic acid (23235-01-0,23235-03-2,50428-03-0,64165-64-6) → methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate (1195787-86-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

4.2: 20 °C / pH 7

5.1: silver trifluoromethanesulfonate / acetonitrile / 20 °C

With copper(l) iodide; thionyl chloride; silver trifluoromethanesulfonate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate (1195787-85-9) → methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate (1195787-86-0)

Guidance literature:

With silver trifluoromethanesulfonate; In acetonitrile; at 60 ℃; for 6h; Product distribution / selectivity;

Reference yield:

(R)-2-amino-4-pentynoic acid methyl ester (78342-50-4) → methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate (1195787-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

2.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

3.2: 20 °C / pH 7

4.1: silver trifluoromethanesulfonate / acetonitrile / 20 °C

With copper(l) iodide; silver trifluoromethanesulfonate; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; acetonitrile;

upstream raw materials:

methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-(([(1,1-dimethylethyl)oxy]carbonyl)amino)-4-pentynoate

(R)-2-aminopent-4-ynoic acid

(R)-2-amino-4-pentynoic acid methyl ester

Downstream raw materials:

methyl (5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-D-prolinate

methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-D-prolinate