methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

Base Information

Chemical Name:methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate
CAS No.:1195787-85-9
Molecular Formula:C₃₁H₂₈F₇N₃O₃
Molecular Weight:623.57
Hs Code.:

Synonyms:methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

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Chemical Property of methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

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Technology Process of methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

There total 4 articles about methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1195787-84-8
methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-(([(1,1-dimethylethyl)oxy]carbonyl)amino)-4-pentynoate

: 1195787-85-9
methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

Guidance literature:: methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-(([(1,1-dimethylethyl)oxy]carbonyl)amino)-4-pentynoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; Cooling with ice;

With sodium hydrogencarbonate; In water; pH=7; Product distribution / selectivity; Saturated solution;

Reference yield:

: 23235-01-0,23235-03-2,50428-03-0,64165-64-6
(R)-2-aminopent-4-ynoic acid

: 1195787-85-9
methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

4.2: 20 °C / pH 7

With copper(l) iodide; thionyl chloride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 78342-50-4
(R)-2-amino-4-pentynoic acid methyl ester

: 1195787-85-9
methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 3 h / 20 °C

2.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / 0.5 h / 100 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

3.2: 20 °C / pH 7

With copper(l) iodide; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water;