(3-azido-4-fluorophenyl)methyl bromomethyl ketone

Base Information

Chemical Name:(3-azido-4-fluorophenyl)methyl bromomethyl ketone
CAS No.:858972-22-2
Molecular Formula:C₉H₇BrFN₃O
Molecular Weight:272.076
Hs Code.:

Synonyms:(3-azido-4-fluorophenyl)methyl bromomethyl ketone

Suppliers and Price of (3-azido-4-fluorophenyl)methyl bromomethyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3-azido-4-fluorophenyl)methyl bromomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3-azido-4-fluorophenyl)methyl bromomethyl ketone

There total 7 articles about (3-azido-4-fluorophenyl)methyl bromomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 858972-21-1
(3-azido-4-fluorophenyl)methyl diazomethyl ketone

: 858972-22-2
(3-azido-4-fluorophenyl)methyl bromomethyl ketone

Guidance literature:: With hydrogen bromide; acetic acid; In water; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.04.025

Reference yield:

: 858972-16-4
ethyl 2-(4-fluoro-3-nitrophenyl)acetate

: 858972-22-2
(3-azido-4-fluorophenyl)methyl bromomethyl ketone

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / hydrogen / Pd/C / ethanol / 20 °C / atmospheric pressure

2: 95 percent / NaNO₂; NaN₃; trifluoroacetic acid / 0.17 h / 0 °C

3: 93 percent / potassium hydroxide / diethyl ether; ethanol / 0 - 20 °C

4: thionyl chloride / 1.5 h / Heating

5: 2.23 g / diethyl ether / 0 °C

6: 93 percent / acetic acid; HBr / H₂O / 0 - 20 °C

With potassium hydroxide; thionyl chloride; sodium azide; hydrogen bromide; hydrogen; acetic acid; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In diethyl ether; ethanol; water;
DOI:10.1016/j.tet.2005.04.025

Reference yield:

: 587-88-2
ethyl 2-(4-fluorophenyl)acetate

: 858972-22-2
(3-azido-4-fluorophenyl)methyl bromomethyl ketone

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / H₂SO₄; HNO₃ / 0.58 h / 0 °C

2: 94 percent / hydrogen / Pd/C / ethanol / 20 °C / atmospheric pressure

3: 95 percent / NaNO₂; NaN₃; trifluoroacetic acid / 0.17 h / 0 °C

4: 93 percent / potassium hydroxide / diethyl ether; ethanol / 0 - 20 °C

5: thionyl chloride / 1.5 h / Heating

6: 2.23 g / diethyl ether / 0 °C

7: 93 percent / acetic acid; HBr / H₂O / 0 - 20 °C

With potassium hydroxide; thionyl chloride; sodium azide; sulfuric acid; hydrogen bromide; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In diethyl ether; ethanol; water;
DOI:10.1016/j.tet.2005.04.025