(3-azido-4-fluorophenyl)methyl diazomethyl ketone

Base Information

• Chemical Name: (3-azido-4-fluorophenyl)methyl diazomethyl ketone
• CAS No.: 858972-21-1
• Molecular Formula: C₉H₆FN₅O
• Molecular Weight: 219.178
• Mol file: 858972-21-1.mol

Synonyms:(3-azido-4-fluorophenyl)methyl diazomethyl ketone

Chemical Property of (3-azido-4-fluorophenyl)methyl diazomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-azido-4-fluorophenyl)methyl diazomethyl ketone

There total 6 articles about (3-azido-4-fluorophenyl)methyl diazomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-fluoro-3-nitrophenyl)acetate (858972-16-4) → (3-azido-4-fluorophenyl)methyl diazomethyl ketone (858972-21-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / hydrogen / Pd/C / ethanol / 20 °C / atmospheric pressure

2: 95 percent / NaNO₂; NaN₃; trifluoroacetic acid / 0.17 h / 0 °C

3: 93 percent / potassium hydroxide / diethyl ether; ethanol / 0 - 20 °C

4: thionyl chloride / 1.5 h / Heating

5: 2.23 g / diethyl ether / 0 °C

With potassium hydroxide; thionyl chloride; sodium azide; hydrogen; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1016/j.tet.2005.04.025

Reference yield:

ethyl 2-(4-fluorophenyl)acetate (587-88-2) → (3-azido-4-fluorophenyl)methyl diazomethyl ketone (858972-21-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 79 percent / H₂SO₄; HNO₃ / 0.58 h / 0 °C

2: 94 percent / hydrogen / Pd/C / ethanol / 20 °C / atmospheric pressure

3: 95 percent / NaNO₂; NaN₃; trifluoroacetic acid / 0.17 h / 0 °C

4: 93 percent / potassium hydroxide / diethyl ether; ethanol / 0 - 20 °C

5: thionyl chloride / 1.5 h / Heating

6: 2.23 g / diethyl ether / 0 °C

With potassium hydroxide; thionyl chloride; sodium azide; sulfuric acid; hydrogen; nitric acid; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1016/j.tet.2005.04.025

Reference yield:

ethyl (2-azido-4-fluorophenyl)acetate (858972-19-7) → (3-azido-4-fluorophenyl)methyl diazomethyl ketone (858972-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / potassium hydroxide / diethyl ether; ethanol / 0 - 20 °C

2: thionyl chloride / 1.5 h / Heating

3: 2.23 g / diethyl ether / 0 °C

With potassium hydroxide; thionyl chloride; In diethyl ether; ethanol;

DOI:10.1016/j.tet.2005.04.025

upstream raw materials:

diazomethane

ethyl (2-azido-4-fluorophenyl)acetate

ethyl 2-(4-fluoro-3-nitrophenyl)acetate

ethyl 2-(4-fluorophenyl)acetate

Downstream raw materials:

8-benzyl-2-(3-azido-4-fluorophenylmethyl)-6-(4-hydroxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one

(3-azido-4-fluorophenyl)methyl bromomethyl ketone