Z-Ser(tbu)-osu

Base Information

• Chemical Name: Z-Ser(tbu)-osu
• CAS No.: 19460-97-0
• Molecular Formula: C19H24 N2 O7
• Molecular Weight: 392.4
• DSSTox Substance ID: DTXSID20550491
• Nikkaji Number: J82.867J
• Wikidata: Q82429879
• Mol file: 19460-97-0.mol

Synonyms:Z-SER(TBU)-OSU;19460-97-0;Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester;Z-L-Ser(tBu)-OSu;(2,5-dioxopyrrolidin-1-yl) (2S)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)propanoate;(S)-2,5-Dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoate;Z-Ser(but)-Osu;SCHEMBL7327877;DTXSID20550491;HSJCWCOSSJNXAN-AWEZNQCLSA-N;MFCD00153342;AKOS027327855;AS-46850;F10719;2,5-Dioxopyrrolidin-1-yl N-[(benzyloxy)carbonyl]-O-tert-butyl-L-serinate;(S)-2,5-dioxopyrrolidin-1-yl 2-(benzyloxycarbonylamino)-3-tert-butoxypropanoate;(S)-2,5-Dioxopyrrolidin-1-yl2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoate;N-alpha-BenZyloxycarbonyl-O-t-butyl-L-serine succinimidyl ester (CbZ-L-Ser(tBu)-OSu)

Chemical Property of Z-Ser(tbu)-osu

Chemical Property:

• PSA: 111.24000
• LogP: 2.03250
• Storage Temp.: -15°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 392.15835111
• Heavy Atom Count: 28
• Complexity: 578

Purity/Quality:

99% ^*data from raw suppliers

Z-Ser(TBU)-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OCC(C(=O)ON1C(=O)CCC1=O)NC(=O)OCC2=CC=CC=C2
• Isomeric SMILES: CC(C)(C)OC[C@@H](C(=O)ON1C(=O)CCC1=O)NC(=O)OCC2=CC=CC=C2

Technology Process of Z-Ser(tbu)-osu

There total 1 articles about Z-Ser(tbu)-osu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-benzyloxycarbonyl-O-t-butyl-L-serine (1676-75-1) → Z-Ser(But)-ONSu (19460-97-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/chem.201302732

Reference yield: 80.0%

Z-Ser(But)-ONSu (19460-97-0) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → Z-Ser(tBu)-Pro-OH (39748-01-1)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 24h;

DOI:10.1007/BF00808774

Reference yield: 78.0%

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid (2418-95-3) + Z-Ser(But)-ONSu (19460-97-0) → Z-L-Ser(tBu)-L-Lys(Boc)OH (85382-01-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; a) 1 h, 0 deg C, b) 24 h, r.t.;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-benzyloxycarbonyl-O-t-butyl-L-serine

Downstream raw materials:

Z-L-Ser(tBu)-L-Lys(Boc)OH

Z-Ser(Bu^t)-Arg(Tos)-Leu-OH

Z-Ser(Bu-t)-Asp(OBu-t)-Phe-Ser(Bu-t)-OH

Z-Ser(tBu)-Pro-OH