(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

Base Information

Chemical Name:(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole
CAS No.:1415764-02-1
Molecular Formula:C₁₇H₁₃F₃INO
Molecular Weight:431.196
Hs Code.:

Synonyms:(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

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Technology Process of (4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

There total 4 articles about (4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 3-(trifluoromethyl)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-2-iodobenzamide

: 1415764-02-1
(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;
DOI:10.1021/jo302393u

Reference yield:

: 313-12-2
2-amino-3-(trifluoromethyl)benzoic acid

: 1415764-02-1
(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 0.42 h / 0 °C / Cooling with ice

1.2: 0.17 h

1.3: 16 h / 20 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / benzene / 3 h / 0 °C / Reflux; Inert atmosphere

3.1: triethylamine / dichloromethane / 18 h / 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; di-isopropyl azodicarboxylate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jo302393u

Reference yield:

: 766473-89-6
3-(trifluoromethyl)-2-iodobenzoic acids

: 1415764-02-1
(4S,5S)-2-(3-(trifluoromethyl)-2-iodophenyl)-4,5-dihydro-4-methyl-5-phenyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / benzene / 3 h / 0 °C / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 18 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

With thionyl chloride; di-isopropyl azodicarboxylate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo302393u