[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

Base Information

Chemical Name:[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone
CAS No.:1402048-13-8
Molecular Formula:C₄₀H₅₆N₂O₃S₂
Molecular Weight:677.028
Hs Code.:

Synonyms:[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

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Chemical Property of [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

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Technology Process of [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

There total 5 articles about [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 10400-19-8
3-pyridinecarbonyl chloride

: 1402048-10-5
2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol

: 1402048-13-8
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402048-13-8
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402048-13-8
[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-pyridin-3-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran;