methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

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Chemical Name:methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate
CAS No.:937055-00-0
Molecular Formula:C₃₀H₂₈ClN₃O₆
Molecular Weight:562.022
Hs Code.:

Synonyms:methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

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Chemical Property of methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

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Technology Process of methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

There total 10 articles about methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6937-03-7
methyl 2-aminoisonicotinate

: 937054-53-0
3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propionic acid

: 937055-00-0
methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; at 20 ℃; for 18h;

Reference yield:

: 937057-52-8
methyl (E)-3-(1-{4-chloro-2-[(2,3-dimethoxyphenyl)(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

: 937055-00-0
methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: Resolution of racemate

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

3.2: 3 h / 0 °C

4.1: triethylamine / dichloromethane / 3 h / 0 °C

5.1: dimethyl sulfoxide / 13 h / 50 °C

6.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

6.2: 0 °C

7.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / 18 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; isopropyl alcohol; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 937054-14-3
methyl [(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

: 937055-00-0
methyl 2-({3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}amino)isonicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

1.2: 3 h / 0 °C

2.1: triethylamine / dichloromethane / 3 h / 0 °C

3.1: dimethyl sulfoxide / 13 h / 50 °C

4.1: sodium hydroxide; water; isopropyl alcohol / 96 h / Heating / reflux

4.2: 0 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / 18 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; isopropyl alcohol; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;