tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

Base Information

Chemical Name:tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate
CAS No.:1446444-63-8
Molecular Formula:C₁₆H₁₃ClF₃NO₃
Molecular Weight:359.732
Hs Code.:

Synonyms:tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

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Technology Process of tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

There total 1 articles about tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 209328-72-3
5-chloro-6-fluoropyridin-3-ol

: 20372-66-1
methyl 2,4,5-trifluorobenzoate

: 1446444-63-8
tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

Reference yield: 89.0%

: 1446444-63-8
tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

: 1446444-62-7
4-((5-chloro-6-fluoropyridin-3-yl)oxy)-2,5-difluorobenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1446444-63-8
tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

: 1446444-50-3
4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluoro-N-[(dimethylamino)sulfonyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 30 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;