4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Base Information

Chemical Name:4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide
CAS No.:1446444-44-5
Molecular Formula:C₁₇H₁₅ClF₅N₃O₅S
Molecular Weight:503.834
Hs Code.:

Synonyms:4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

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Chemical Property of 4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

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Technology Process of 4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

There total 5 articles about 4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 374-01-6
1,1,1-trifluoroisopropanol

: 1446444-50-3
4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluoro-N-[(dimethylamino)sulfonyl]benzamide

: 1446444-44-5
4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 80 - 100 ℃; for 20h;

Reference yield:

: 20372-66-1
methyl 2,4,5-trifluorobenzoate

: 1446444-44-5
4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 30 °C

4: sodium hydride / tetrahydrofuran / 20 h / 80 - 100 °C

With dmap; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1446444-63-8
tert-butyl 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2,5-difluorobenzoate

: 1446444-44-5
4-((5-chloro-6-((1,1,1-trifluoropropan-2-yl)oxy)pyridin-3-yl)oxy)-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 30 °C

3: sodium hydride / tetrahydrofuran / 20 h / 80 - 100 °C

With dmap; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;