2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

Base Information

Chemical Name:2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol
CAS No.:1384984-29-5
Molecular Formula:C₁₇H₂₁FN₄O₂
Molecular Weight:332.378
Hs Code.:

Synonyms:2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

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Chemical Property of 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

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Technology Process of 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

There total 8 articles about 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1384984-28-4
2-[5-(4-amino-2-fluoro-5-nitro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

: 1384984-29-5
2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; triethylamine; In methanol; for 4h; under 2327.23 Torr;
DOI:10.1021/jm500563g

Reference yield:

: 1384984-24-0
3-fluoro-2-(tetrahydrofuran-2-yl)aniline

: 1384984-29-5
2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 1 h / -20 - -10 °C

2.1: tetrahydrofuran / 2 - 35 °C

2.2: 2.67 h / 30 - 41 °C

3.1: water; sulfuric acid / 1,4-dioxane / 120 h / Reflux

4.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / Inert atmosphere

4.2: Reflux

5.1: triethylamine; hydrogen / 5%-palladium/activated carbon / water; tetrahydrofuran; methanol / 2327.23 Torr / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; water; hydrogen; sodium hydrogencarbonate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl methyl ether; water; acetonitrile; 4.1: Suzuki Coupling;

Reference yield:

: 1384984-25-1
4-bromo-3-fluoro-2-(tetrahydrofuran-2-yl)aniline

: 1384984-29-5
2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 - 35 °C

1.2: 2.67 h / 30 - 41 °C

2.1: water; sulfuric acid / 1,4-dioxane / 120 h / Reflux

3.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / Inert atmosphere

3.2: Reflux

4.1: triethylamine; hydrogen / 5%-palladium/activated carbon / water; tetrahydrofuran; methanol / 2327.23 Torr / Inert atmosphere

With sulfuric acid; water; hydrogen; sodium hydrogencarbonate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; 3.1: Suzuki Coupling;