Technology Process of 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol
There total 8 articles about 2-[5-(4,5-diamino-2-fluoro-3-tetrahydrofuran-2-yl-phenyl)pyrimidin-2-yl]propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen; triethylamine;
In
methanol;
for 4h;
under 2327.23 Torr;
DOI:10.1021/jm500563g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 1 h / -20 - -10 °C
2.1: tetrahydrofuran / 2 - 35 °C
2.2: 2.67 h / 30 - 41 °C
3.1: water; sulfuric acid / 1,4-dioxane / 120 h / Reflux
4.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / Inert atmosphere
4.2: Reflux
5.1: triethylamine; hydrogen / 5%-palladium/activated carbon / water; tetrahydrofuran; methanol / 2327.23 Torr / Inert atmosphere
With
N-Bromosuccinimide; sulfuric acid; water; hydrogen; sodium hydrogencarbonate; triethylamine;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl methyl ether; water; acetonitrile;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 2 - 35 °C
1.2: 2.67 h / 30 - 41 °C
2.1: water; sulfuric acid / 1,4-dioxane / 120 h / Reflux
3.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / Inert atmosphere
3.2: Reflux
4.1: triethylamine; hydrogen / 5%-palladium/activated carbon / water; tetrahydrofuran; methanol / 2327.23 Torr / Inert atmosphere
With
sulfuric acid; water; hydrogen; sodium hydrogencarbonate; triethylamine;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
3.1: Suzuki Coupling;