2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER

Base Information

• Chemical Name: 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER
• CAS No.: 19350-66-4
• Molecular Formula: C14H19 N O6
• Molecular Weight: 297.308
• Hs Code.: 2933399090
• Mol file: 19350-66-4.mol

Synonyms:3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylicacid; PP 145; PP 145 (antioxidant)

Chemical Property of 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER

Chemical Property:

• Vapor Pressure: 2.26E-09mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 450.5°Cat760mmHg
• PKA: 1.47±0.70(Predicted)
• Flash Point: 226.3°C
• PSA: 101.93000
• Density: 1.23g/cm³
• LogP: 1.29340
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

AV-153freebase ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER

There total 2 articles about 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) + Glyoxilic acid (298-12-4) → 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester (19350-66-4)

Guidance literature:

With acetic acid; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.1c01243

Reference yield: 20.0%

ethyl 3-aminobut-2-enoate (626-34-6) + Glyoxilic acid (298-12-4) → 2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester (19350-66-4)

Guidance literature:

With acetic acid; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.orglett.1c03908

Reference yield: 100.0%

2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester (19350-66-4) + benzylamine (100-46-9) → diethyl-2,6-dimethyl-4-(benzylcarbamoyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:

2,6-dimethyl-1,4-dihydropyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; With triethylamine; isobutyl chloroformate; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

benzylamine; In dichloromethane; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.202000224

upstream raw materials:

ethyl aminocrotonate

Glyoxilic acid

ethyl 3-aminobut-2-enoate

Downstream raw materials:

pentafluorophenyl 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinate

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