(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Base Information

Chemical Name:(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate
CAS No.:1072133-92-6
Molecular Formula:C₂₉H₃₅Cl₃O₄
Molecular Weight:553.953
Hs Code.:

Synonyms:(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

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Chemical Property of (R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

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Technology Process of (R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

There total 3 articles about (R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 1267475-21-7
(R,E)-3-(3-(3-hydroxyprop-1-en-1-yl)phenyl)-12-methyl-8-methylenetridec-11-en-6-ynal

: 1072133-92-6
(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Guidance literature:: With pyridine; dmap; In dichloromethane; at -40 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.11.083

Reference yield:

: (2E)-3-(3-(12-methyl-8-methylene-1-oxotrideca-2,11-dien-6-yn-3-yl)phenyl)allyl 1,1,1-trichloro-2-methylpropan-2-yl carbonate

: (S,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl 1,1,1-trichloro-2-methylpropan-2-yl carbonate

: 1072133-92-6
(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Guidance literature:: With (2R)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In chloroform; at -30 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja803299h

Reference yield:

: 1267475-19-3
(R)-3-((R)-3-(3-((E)-3-hydroxyprop-1-en-1-yl)phenyl)-12-methyl-8-methylenetridec-11-en-6-ynoyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

: 1072133-92-6
(R,E)-3-(3-(12-methyl-8-methylene-1-oxotridec-11-en-6-yn-3-yl)phenyl)allyl (1,1,1-trichloro-2-methylpropan-2-yl) carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / hexane; toluene / -78 °C

2: pyridine; dmap / dichloromethane / -40 °C / Inert atmosphere

With pyridine; dmap; diisobutylaluminium hydride; In hexane; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2010.11.083