(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

Base Information

Chemical Name:(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid
CAS No.:209845-76-1
Molecular Formula:C₁₀H₆F₄O₂
Molecular Weight:234.15
Hs Code.:

Synonyms:(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

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Technology Process of (Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

There total 4 articles about (Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 127211-25-0
ethyl (Z)-2-fluoro-3-[4-(trifluoromethyl)phenyl]acrylate

: 209845-76-1
(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; for 18h; Reflux; Inert atmosphere;
DOI:10.1002/chem.201405119

Reference yield: 71.0%

: 1198794-74-9
C₁₀H₆ClF₇O

: 209845-76-1
(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

Guidance literature:: C₁₀H₆ClF₇O; With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃; for 2h; Inert atmosphere;

With methanesulfonyl chloride; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

With N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydroxide; In tetrahydrofuran; hexane; at 20 ℃; for 2h; stereospecific reaction; Inert atmosphere;
DOI:10.1002/chem.201100900

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 74670-68-1
1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene

: 209845-76-1
(Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid

: C₁₀H₆F₄O₂

Guidance literature:: With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium dichloride; In N,N-dimethyl acetamide; at 25 ℃; under 760.051 Torr; Irradiation;
DOI:10.1039/c9sc01336a