Technology Process of phenyl 2-(benzyloxy)-5-methoxy-6-methyl-3-aminobenzoate
There total 7 articles about phenyl 2-(benzyloxy)-5-methoxy-6-methyl-3-aminobenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dithionite;
In
tetrahydrofuran; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 2.5 h / 0 °C
1.2: 2 h / 25 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C
3.1: dmap; triethylamine / dichloromethane / 12 h / 25 °C
4.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 20 °C
6.1: acetic anhydride; copper(II) nitrate hydrate / 3 h / 0 - 20 °C
7.1: sodium dithionite / water; tetrahydrofuran / 20 °C
With
2,2,6,6-tetramethyl-piperidine; dmap; n-butyllithium; sodium dithionite; oxalyl dichloride; copper(II) nitrate hydrate; acetic anhydride; boron tribromide; sodium hydride; triethylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C
2.1: dmap; triethylamine / dichloromethane / 12 h / 25 °C
3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
4.2: 20 °C
5.1: acetic anhydride; copper(II) nitrate hydrate / 3 h / 0 - 20 °C
6.1: sodium dithionite / water; tetrahydrofuran / 20 °C
With
dmap; sodium dithionite; oxalyl dichloride; copper(II) nitrate hydrate; acetic anhydride; boron tribromide; sodium hydride; triethylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
