(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

Base Information

Chemical Name:(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine
CAS No.:98245-11-5
Molecular Formula:C₂₈H₃₂N₄O
Molecular Weight:440.588
Hs Code.:

Synonyms:(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

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Chemical Property of (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

Chemical Property:

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Technology Process of (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

There total 10 articles about (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75970-76-2
1-(phenylmethyl)-N-(4-piperidinyl)-1H-benzimidazol-2-amine

: 98245-11-5
(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/jm00150a029

Reference yield:

: 2719-30-4
o-nitrophenylisothiocyanate

: 98245-11-5
(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 25 °C

2: H₂, NH₃ / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

3: yellow HgO, sulfur / ethanol / 2 h / Heating

4: Na₂CO₃ / dimethylformamide

With ammonia; hydrogen; sodium carbonate; sulfur; mercury(II) oxide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 98245-11-5
(1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate, potassium iodide / various solvent(s) / 18 h / Heating

2: 2 N HCl / Heating

3: H₂, NH₃ / 10 percent Pd/C / methanol

4: ethanol / 25 °C

5: H₂, NH₃ / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

6: yellow HgO, sulfur / ethanol / 2 h / Heating

7: Na₂CO₃ / dimethylformamide

With hydrogenchloride; ammonia; hydrogen; sodium carbonate; sulfur; potassium iodide; mercury(II) oxide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029