N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide

Base Information

• Chemical Name: N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide
• CAS No.: 1623775-24-5
• Molecular Formula: C₂₇H₂₈N₄O₂
• Molecular Weight: 440.545
• Mol file: 1623775-24-5.mol

Synonyms:N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide

Chemical Property of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide

There total 5 articles about N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide (1623774-99-1) + (3-methoxyphenyl)magnesium bromide (36282-40-3) → N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide (1623775-24-5)

Guidance literature:

N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide; (3-methoxyphenyl)magnesium bromide; With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

With 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With 1,2-dichloro-2-methylpropane; In tetrahydrofuran; at 55 ℃; for 36h;

DOI:10.1002/anie.201311024

Reference yield: 84.0%

3-methoxy-1-iodobenzene (766-85-8) + N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide (1623774-99-1) → N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide (1623775-24-5)

Guidance literature:

With silver(I) acetate; palladium diacetate; In toluene; at 110 ℃; for 16h; Reagent/catalyst; Temperature; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201601045

Reference yield:

2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine (1310826-33-5) → N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide (1623775-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / dichloromethane / 5 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 12 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide; iron(III) chloride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 0.17 h / 20 °C

2.3: 36 h / 55 °C

With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine; N,N-dimethyl-formamide; zinc dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.201311024

upstream raw materials:

N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide

(3-methoxyphenyl)magnesium bromide

2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

benzyl azide